Abstract Background The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillatory potentials are also involved in adrenergic control of SAN discharge. Methods Vos and ThVos were visualized by superfusing guinea pig SAN in high [K+]o. https://www.opheliasmuse.com/