Abstract Background Our randomized controlled clinical trial will explore the potential of bazedoxifene plus conjugated estrogen to modulate breast tissue-based risk biomarkers as a surrogate for breast cancer risk reduction. This paper investigates the statistical design features of the trial and the rationale for the final choice of its design. Group sequential designs are a popular... https://www.alarecre.com/NHL-Vegas-Golden-Knights-Black-Background-iPhone-14-Plus-Skin-p42149/