This refers to how an allosteric modulator affects signaling for a particular orthosteric agonist. For instance, an allosteric modulator might alter THC signaling, but not endogenous cannabinoid signaling. A significant probable endogenous detrimental allosteric modulator for CB1 would be the steroid hormone, pregnenolone [forty–42]. Some (nevertheless not all [forty three–forty https://howtoconvertiraintogold09987.losblogos.com/31973054/fascination-about-cannabis-strains