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When an opiate binds as an agonist for the GPCR, there will become a signaling cascade causing the inhibition of adenylate cyclase and calcium ion channels with the stimulation of potassium ion channels. The net effect of such modifications is really a lowered intracellular cAMP and hyperpolarization on the neuronal https://opioids-and-constipation17048.blogcudinti.com/28698704/the-fact-about-what-pill-has-80-on-it-that-no-one-is-suggesting

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